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apalutamide will reduce the extent or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with medication which might be CYP2C19 substrates may end up in decreased exposure to these drugs.Efficacy and safety of parenteral diazepam hasn't been